Dennis E Hruby Selected Research

Poxviridae Infections

1/2013	Pharmacokinetics and interspecies allometric scaling of ST-246, an oral antiviral therapeutic for treatment of orthopoxvirus infection.
9/2012	Safety and pharmacokinetics of the anti-orthopoxvirus compound ST-246 following a single daily oral dose for 14 days in human volunteers.
7/2012	Pharmacokinetic comparison of a single oral dose of polymorph form i versus form V capsules of the antiorthopoxvirus compound ST-246 in human volunteers.
1/2012	Screening for vaccinia virus egress inhibitors: separation of IMV, IEV, and EEV.
9/2011	Effective antiviral treatment of systemic orthopoxvirus disease: ST-246 treatment of prairie dogs infected with monkeypox virus.
1/2011	Comparison of the safety and pharmacokinetics of ST-246® after i.v. infusion or oral administration in mice, rabbits and monkeys.
11/2010	Development of ST-246® for Treatment of Poxvirus Infections.
6/2010	Safety and pharmacokinetics of the antiorthopoxvirus compound ST-246 following repeat oral dosing in healthy adult subjects.
5/2009	ST-246 antiviral efficacy in a nonhuman primate monkeypox model: determination of the minimal effective dose and human dose justification.
3/2009	In vitro efficacy of ST246 against smallpox and monkeypox.

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Dennis E Hruby Research Topics

Disease

21	Smallpox (Variola) 01/2021 - 11/2004
14	Poxviridae Infections 01/2013 - 12/2006
12	Infections 07/2015 - 09/2004
9	Vaccinia 01/2021 - 03/2006
5	Mpox (monkeypox) 01/2021 - 04/2007
4	Body Weight (Weight, Body) 01/2018 - 02/2007
3	Cowpox 01/2019 - 01/2007
3	Viremia 01/2013 - 05/2009
2	Virus Diseases (Viral Diseases) 04/2007 - 01/2007
1	Dengue (Dengue Fever) 01/2013
1	Rift Valley Fever 07/2012
1	Exanthema (Rash) 09/2011
1	Lassa Fever (Fever, Lassa) 04/2011
1	Fever (Fevers) 11/2008
1	Vesicular Stomatitis 11/2008
1	Neutropenia 05/2008

Drug/Important Bio-Agent (IBA)

28	tecovirimatIBA 01/2021 - 01/2007
19	Antiviral Agents (Antivirals)IBA 01/2019 - 11/2004
7	VaccinesIBA 04/2013 - 06/2005
5	Smallpox Vaccine (Vaccine, Smallpox)FDA Link 07/2015 - 04/2008
4	Pharmaceutical PreparationsIBA 12/2013 - 01/2007
2	AerosolsIBA 01/2018 - 08/2008
2	brincidofovirIBA 11/2012 - 11/2007
2	Biological Warfare AgentsIBA 01/2012 - 05/2011
2	ST-193IBA 04/2011 - 11/2008
2	Proteins (Proteins, Gene)FDA Link 12/2006 - 03/2006
1	ACAM2000IBA 07/2015
1	Secretory Immunoglobulin A (SIgA)IBA 12/2013
1	CytokinesIBA 01/2013
1	ST-148IBA 01/2013
1	Immunoglobulins (Immunoglobulin)IBA 11/2012
1	Viral DNAIBA 09/2011
1	Ribavirin (Virazole)FDA LinkGeneric 04/2011
1	GTP-Binding Proteins (G-Protein)IBA 11/2008
1	Neutralizing AntibodiesIBA 02/2008
1	Biological ProductsIBA 01/2008
1	Dihydrotachysterol (AT 10)IBA 11/2007
1	Peptide Hydrolases (Proteases)FDA Link 10/2007
1	UbiquitinIBA 10/2007
1	97-kDa Golgi complex autoantigenIBA 12/2006
1	Membrane Proteins (Integral Membrane Proteins)IBA 03/2006
1	Tetracycline (Achromycin)FDA LinkGeneric 09/2004

Therapy/Procedure

9	Therapeutics 01/2018 - 05/2009
1	Oncolytic Virotherapy 01/2021
1	Oral Administration 01/2013
1	Intravenous Injections 05/2009
1	Treatment Delay 02/2007